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Science

Hundreds screened. Five earned the formula.

Hundreds of botanicals were screened. Only the five HairBooster™ formula cores validated by human research¹ stayed — from follicle to stress, density to defense, one formula with full-spectrum coverage of common hair-loss causes, no compromise on results².

Flagship botanical

Science card for Italian Annurca apple

Flagship botanical

Italian Annurca apple

Malus pumila Mill. cv. Annurca

Grown in Southern Italy's volcanic soils, a water-extracted polyphenol concentrate rich in procyanidin B2, chlorogenic acid, and apple polyphenols — full-spectrum support across hair count, hair weight, and density.

+118%¹
Hair count
-26%¹
Shedding
Science card for Ashwagandha

Flagship botanical

Ashwagandha

Withania somnifera

From the traditional Ayurvedic herbal tradition of India, a whole-herb standardized extract (≥5% withanolides) that improves stress resilience and sleep quality².

-44%¹
Perceived stress

Specialized botanical

Specialized botanical

Specialized botanicalAntioxidant

Mixed tocotrienols

Elaeis guineensis Jacq.

A palm-source tocotrienol-rich fraction dominated by gamma-tocotrienol — the lesser-known, more lipid-soluble branch of the vitamin E family.

+34.5%¹
Hair count
View study→

Specialized botanical

Specialized botanicalDHT defense

Pumpkin seed 20:1 concentrate

Cucurbita pepo L.

A 20:1 pumpkin seed concentrate standardised to β-sitosterol — the most-researched phytosterol, associated with countering the challenge of DHT-related hair loss².

  1. Based on human research data.
  2. Product results vary between individuals.
  3. Based on publicly available research.
  4. Flagship botanicals — broad hair-research base.
  5. Specialised botanicals — targeted research evidence.
  6. This product is not a medicine.

References

  1. De Biasio F, et al. A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia. J Appl Cosmetol. 2023;41(2):28–46.
  2. Tenore GC, et al. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. J Med Food. 2018;21(1):90–103. PMID: 28956697
  3. Badolati N, et al. Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation. Nutrients. 2018;10(10):1406. PMID: 30279339
  4. Piccolo M, et al. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Nutrients. 2019;11(12):3041. PMID: 31847069
Science card for Saw palmetto extract

Flagship botanical

Saw palmetto extract

Serenoa repens (W. Bartram) Small

A leading hair-loss-defense botanical, native to the subtropical southeastern United States; a water-extracted berry extract standardized to 45% free fatty acids.

83.3%¹
Users with density increase
-29%¹
Shedding reduction
+40%¹
Hair count
View study→
  • Benedetto N, et al. Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss. FEBS Open Bio. 2024;14:955–967. PMID: 38711215
  • Takahashi T, et al. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. J Invest Dermatol. 1999;112(3):310–316. PMID: 10084307
  • Kamimura A, et al. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study. Br J Dermatol. 2002;146(1):41–51. PMID: 11841365
  • Kamimura A, et al. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529–536. PMID: 11194183
  • Takahashi T, et al. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent. Phytother Res. 2001;15(4):331–336. PMID: 11406858
  • Takahashi T, et al. Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005;4(4):245–249. PMID: 17168871
  • Asghar F, et al. Telogen effluvium: a review of the literature. Cureus. 2020;12(5):e8320. PMID: 32607303
  • Hadshiew IM, et al. Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol. 2004;123(3):455–457. PMID: 15304082
  • Cheah KL, et al. Effect of Ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. PMID: 34559859
  • Fatima K, et al. Safety and efficacy of Withania somnifera for anxiety and insomnia: systematic review and meta-analysis. Hum Psychopharmacol. 2024;39(6):e2911. PMID: 39083548
  • Deshpande A, et al. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020;72:28–36. PMID: 32540634
  • Kelgane SB, et al. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study. Cureus. 2020;12(2):e7083. PMID: 32226684
  • Langade D, et al. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus. 2019;11(9):e5797. PMID: 31728244
  • Langade D, et al. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: a double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021;264:113276. PMID: 32818573
  • Movva N, et al. Comparative evaluation of ashwagandha (Withania somnifera) root extract and melatonin for improving sleep quality in adults: a prospective, randomized, double-blind, placebo-controlled study. Clocks Sleep. 2026;8(2):15. PMID: 42029558
  • Akhgarjand C, et al. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022;36(11):4115–4124. PMID: 36017529
  • Arumugam V, et al. Effects of Ashwagandha (Withania somnifera) on stress and anxiety: a systematic review and meta-analysis. Explore (NY). 2024;20(6):103062. PMID: 39348746
  • Marchi M, et al. The effect of Withania somnifera (ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis. BJPsych Open. 2025;11(6):e260. PMID: 41140145
  • O'Connor J, et al. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. J Med Food. 2022;25(12):1086–1094. PMID: 35984871
  • Jillella A, et al. A prospective, randomized, double-blind, placebo-controlled clinical study of efficacy and safety of Ashwagandha root extract capsule on skin and hair health in healthy adults. Phytother Res. 2026 (online ahead of print). PMID: 41770039
  • Yerram C, et al. Effects of Withania somnifera root extract serum application on hair health in healthy adults: a prospective, double-blind, randomized, parallel, placebo-controlled study. J Ayurveda Integr Med. 2023;14(6):100817. PMID: 38006746
  • Kim SK, et al. Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts — a double-blind, crossover study in healthy adults. Heliyon. 2023;9(12):e22843. PMID: 38144272
  • Evron E, et al. Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. Skin Appendage Disord. 2020;6(6):329–337. PMID: 33313047
  • Prager N, et al. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002;8(2):143–152. PMID: 12006122
  • Rossi A, et al. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012;25(4):1167–1173. PMID: 23298508
  • Sudeep HV, et al. Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects. Clin Cosmet Investig Dermatol. 2023;16:3251–3266. PMID: 38021422
  • Ablon G. The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto (Serenoa repens) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self-Perceived Thinning Hair: 90-Day Results. J Cosmet Dermatol. 2025;24(12):e70585. PMID: 41319217
  • Ablon G. The Safety and Efficacy of a Novel Saw Palmetto (Serenoa repens) Extract for Promoting Hair Growth in Adults With Self-Perceived Thinning Hair: 180-Day Results. J Cosmet Dermatol. 2026;25(2):e70717. PMID: 41652806
  • Zhou L, et al. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. Front Nutr. 2025;12:1719711. PMID: 41561175
  • Broadley D, et al. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: insights from human hair follicle organ culture. Int J Cosmet Sci. 2025. PMID: 41126502
  • Beoy LA, et al. Effects of tocotrienol supplementation on hair growth in human volunteers. Trop Life Sci Res. 2010;21(2):91–99. PMID: 24575202
  • Prie BE, et al. Oxidative stress in androgenetic alopecia. J Med Life. 2016;9(1):79–83. PMID: 27974920
  • Trüeb RM. Oxidative stress and its impact on skin, scalp and hair. Int J Cosmet Sci. 2021;43(S1):S9–S13. PMID: 34424547
  • Upton JH, et al. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. J Invest Dermatol. 2015;135(5):1244–1252. PMID: 25647436
  • Serbinova E, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991;10(5):263–275. PMID: 1649783
  • Yoshida Y, et al. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids. 2003;123(1):63–75. PMID: 12637165
  • Aggarwal BB, et al. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol. 2010;80(11):1613–1631. PMID: 20696139
  • Azzi A. Tocopherols, tocotrienols and tocomonoenols: many similar molecules but only one vitamin E. Redox Biol. 2019;26:101259. PMID: 31254734
  • Traber MG, et al. Diet-derived and topically applied tocotrienols accumulate in skin and protect the tissue against ultraviolet light-induced oxidative stress. Asia Pac J Clin Nutr. 1997;6(1):63–67. PMID: 24394657
  • Ghazali NI, et al. Effects of tocotrienol on aging skin: a systematic review. Front Pharmacol. 2022;13:1006198. PMID: 36299879
  • Cho YH, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med. 2014;2014:549721. PMID: 24864154
  • Ibrahim IM, et al. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: a randomized comparative trial. J Cosmet Dermatol. 2021;20(9):2867–2873. PMID: 33544448
  • Arias EM, et al. A randomized, double-blind, placebo-controlled clinical trial to assess the efficacy of a nutritional supplement in female androgenic alopecia. Dermatol Ther. 2023;2023:3527895. DOI: 10.1155/2023/3527895
  • Piquero-Casals J, et al. Oral supplementation with l-cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in chronic telogen effluvium and androgenetic alopecia: a double-blind, placebo-controlled, randomized clinical study. Skin Appendage Disord. 2025;11(1):27–35. PMID: 39911983
  • Milani M, et al. Impact of a novel dietary supplement on efficacy of pharmacological treatments for androgenic alopecia: a real-life, multicenter, randomized, assessor-blinded trial on 225 subjects. J Cosmet Dermatol. 2025;24(9):e70388. PMID: 40853071
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