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Flagship botanical

Italian Annurca apple

Grown in Southern Italy's volcanic soils, a water-extracted polyphenol concentrate rich in procyanidin B2, chlorogenic acid, and apple polyphenols — full-spectrum support across hair count, hair weight, and density.

Malus pumila Mill. cv. Annurca

Flagship botanical · 250-participant clinical study¹ · measurable at 8 weeks

2026-05-24
+118%¹
Hair count
-26%¹
Shedding

Tenore 2018 (n=250, 8 wk) / De Biasio 2023 (n=80, 180 d)

Flagship botanicalGrowth activation
References←All research
Science card for Italian Annurca apple

Why this matters

One more on the pillow. A few more in the comb. The light on the floor, landing where it shouldn't.

These aren't a warning, but a reminder — the state of your hair can be seen, and it can be measured.

Density, hair count, hair weight, keratin content. Four metrics that turn that hard-to-name feeling back into numbers you can actually read.

Lost density, thinning strands — never a single cause. But whatever the cause, these numbers are hair writing back.

Learning to read them is where this chapter begins.

A single cultivar from Campania

The Annurca apple grows in Campania, Southern Italy — a heritage region under PGI origin protection. Tree age, soil, season — all of it governed.

After harvest, the fruit rests and matures on straw for several weeks. Locals call the practice melaio — an old procedure, and the condition under which this cultivar comes into being.

Extraction uses water as the solvent, concentrating the polyphenols within the fruit — procyanidin B2, chlorogenic acid, and a whole spectrum of apple-polyphenol chemistry. The extract ratio is 4-6:1, meaning six kilograms of fresh fruit reduce to one kilogram of concentrate.

This specification shares its source with the extract used in the Tenore 2018 and De Biasio 2023 clinical studies — same cultivar, same fruit fraction, same solvent, same extract category — the same research-grade standard as the studied active.

The research data

Tenore 2018 (J Med Food)¹ — 250 participants, eight consecutive weeks, 800 mg of water-extracted Annurca apple concentrate daily (the AppleMets branded proprietary extract).

More from the research

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  1. Based on human research data.
  2. Product results vary between individuals.
  3. Specialised botanicals — single-study evidence.

References

  1. Tenore GC, et al. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. J Med Food. 2018;21(1):90–103. PMID: 28956697
  2. De Biasio F, et al. A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia. J Appl Cosmetol. 2023;41(2):28–46.
  • Hair count: from 16.4 to 35.8 hairs per cm² — an absolute gain of about +19 hairs, a relative increase of +118% (the starting baseline was low; both numbers, read together, are the full picture of this result)
  • Hair weight: +37%
  • Keratin content: +36%

De Biasio 2023 (J Appl Cosmetol)¹ — 80 participants, 180 consecutive days, 800 mg daily, against a placebo group.

  • Hair density: +14%
  • Hair weight: +34%
  • Shedding (pull test): -26%
  • Shedding (wash test): -33%
  • At a 30-day follow-up after stopping, the effect remained measurable

Both studies used AppleMets as the test material. HairBooster™ uses the same cultivar, same fruit fraction, same water-extraction method, same range of polyphenol markers — research evidence of the same extract category, not a potency promise on the same batch. This is what this data can carry, and what it cannot reach beyond.

How much a day, and is it enough

The HairBooster™ formula delivers a total of 795 mg per day — a brand-researched blend, five core botanicals plus thirteen foundational actives combined in specific proportions. The exact ratio of each active is part of the formula itself, and is not disclosed on the label.

What can be stated is the two dose tiers of this formula.

1× maintenance (two gummies a day) is the baseline for everyday use. Against the 800 mg of pure Annurca extract per day referenced in the Tenore and De Biasio studies, 1× sits below that dose — a maintenance-oriented design choice, not a research-grade dose replica.

3× intensive (six gummies a day) is the cumulative way of using the same formula. At this tier, the Annurca extract intake moves into the dose range of the published research.

The dose you choose is part of the protocol. Baseline maintenance and research-grade accumulation are two different timelines.

What goes in, and what stays out

Specification is what stays constant about this raw material. Before each batch of Annurca apple concentrate enters inventory, it passes the following tests:

  • Procyanidin B2 (HPLC): spec floor ≥60 µg/g — latest batch measured 90 µg/g
  • Chlorogenic acid (HPLC): spec floor ≥200 µg/g — latest batch measured 350 µg/g
  • Total polyphenols (gallic-acid equivalents, spectrophotometric): spec floor ≥3000 µg/g — latest batch measured 4600 µg/g
  • Extract ratio (DER): 4-6:1
  • Identification: TLC thin-layer chromatography and botanical identification (European Pharmacopoeia standard)

The spec floor is where the promise starts. Measuring above it is the fact of this batch.

This raw material is not a generic apple-polyphenol extract from non-Annurca cultivars, not a polyphenol extract from green or unripe apples, and not any next-generation development of a similar botanical. It is this batch, at this specification, entering this formula — sharing the same cultivar, same fruit fraction, same solvent, and same range of polyphenol markers as the published research.

Same extract category, different batch. This is the closest distance this raw material can travel.

Inside the HairBooster™ formula

The Annurca apple is one of the three flagship botanicals in this formula — standing alongside ashwagandha and saw palmetto, each carrying its own coordinates under its own research.

Sharing the formula are two specialized botanicals (mixed tocotrienols, pumpkin seed 20:1 concentrate) and thirteen foundational actives (B-vitamins, iodine, selenium, niacinamide, biotin, zinc, vitamin D3, and more).

Five cores, thirteen foundations — designed, not assembled.

References

  1. Tenore GC, et al. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. J Med Food. 2018;21(1):90–103. PMID: 28956697
  2. De Biasio F, et al. A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia. J Appl Cosmetol. 2023;41(2):28–46.
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